WebMar 8, 2024 · Potassium dichromate (PD) is an environmental xenobiotic commonly recognized as teratogenic, carcinogenic, and mutagenic in animals and humans. The present study was conducted to investigate the role of tangeretin (TNG) as a neuro-protective drug against PD-induced brain injury in rats. Thirty-two male adult Wistar rats were blindly … WebAbstract. Tangeretin, a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several …
Down-regulating Nrf2 by tangeretin reverses multiple drug ... - PubMed
WebDec 1, 2024 · Nrf2 Tangeretin 1. Introduction Lung cancer is one of the leading causes of mortality among cancer diseases, and non-small cell lung cancer (NSCLC) accounted for more than 85 % of patients with lung cancer. The first-line treatment is chemotherapy for NSCLC patients without apparent gene mutations or with unknown mutations. WebMay 1, 2015 · Effect of tangeretin on Nrf2 EMSA (A), Comet assay (B) and DNA fragmentation assay (C) in the liver tissues of control and experimental animals. ... reduces the xenobiotic-induced genotoxicity and enhances the Nrf2 mediated antioxidant effect in the liver of DMBA induced rats as evidenced from western blot and PCR analysis data. … piano tools supplies
Down-regulating Nrf2 by tangeretin reverses multiple drug
WebJul 10, 2024 · The involvement of heme oxygenase 1 (HO-1) in the modulation of the antinociceptive effects of opioids in type 1 diabetes has been demonstrated but the role played by the transcription factor Nrf2 in the regulation of painful neuropathy and in the effects and expression of δ-opioid receptors (DOR) in type 2 diabetes, has not been studied. WebJul 14, 2024 · AMPK Enhances Transcription of Selected Nrf2 Target Genes via Negative Regulation of Bach1 Front Cell Dev Biol. 2024 Jul 14;8:628. doi: 10.3389 ... Focusing on selected genes with positive regulation by Nrf2 and either positive or no further regulation by AMPK, we revealed that altered Nrf2 levels could not account for the distinct extent of ... WebDec 1, 2024 · Nrf2 Knockdown with siRNA or tangeretin (TG, a flavonoid isolated from citrus peels) inhibited the MDR cell growth by suppressing the Nrf2 pathway, and efficiently enhanced the anti-tumor effects of paclitaxel and AZD9291 (the third generation of TKI) in A549/T or H1975, respectively. piano toucher lourd