Organic anion transporter protein
Witrynamolecular mechanism for PSP transport from the blood into hepatocytes is unclear. In the present study, six human major hepatic uptake transporters expressed on the … Witryna13 lut 2024 · Abstract. Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible …
Organic anion transporter protein
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Witryna11.2.3.1.3 Organic anion-transporting peptides. OATs and organic cation transporters (OCTs) are two of the major transporter families responsible for the absorption, distribution, and elimination of environmental xenobiotics, plant or animal toxins, and drugs. Although both transport systems have distinct substrate preferences, OAT is … WitrynaOrganic anion transporters (OATs) are the secondary/tertiary active transporter proteins that regulate anion balance in the body. They are primarily expressed in …
The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the … Zobacz więcej OAT1 functions as organic anion exchanger. When the uptake of one molecule of an organic anion is transported into a cell by an OAT1 exchanger, one molecule of an endogenous Zobacz więcej Known substrates of OAT1 include para-aminohippurate (PAH), dicarboxylates, prostaglandins, cyclic nucleotides, urate, folate, diuretics, ACE inhibitors, antiviral agents, Zobacz więcej Nucleoside analogs are a class of antiviral drugs that work by inhibiting viral nucleic acid synthesis. The nucleoside analogs acyclovir (ACV), zidovudine (AZT), didanosine (ddI), zalcitabine (ddC), lamivudine (3TC), stavudine (d4T), trifluridine, Zobacz więcej Alterations in the expression and function of OAT1 play important roles in intra- and inter-individual variability of the therapeutic efficacy and the toxicity of many drugs. As a result, the … Zobacz więcej • Solute carrier family Zobacz więcej • Hosoyamada M, Sekine T, Kanai Y, Endou H (1999). "Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney". Am. J. … Zobacz więcej Witryna29 mar 2024 · This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri …
WitrynaOfficial Symbol : SLCO3A1 Official Name : solute carrier organic anion transporter family, member 3A1 EnsemblGene ID : Other Names : solute carrier family 21 (organic anion transporter), member 11, OATPRP3, FLJ40478, OATP3A1, solute carrier organic anion transporter family member 3A1, PGE1 transporter, SLC21A11, … Witryna7 lis 2024 · 2. Transporters involved in the handling of uric acid in vivo. Uric acid possesses two ionizable groups with pKa values of 5.4 and 10.3; as such, this metabolite exists as a monovalent urate anion under physiological conditions with pH 7.4 [6,7].This ionized form is not diffusible across biological membranes; therefore, both excretion …
WitrynaObjectives: Recent reports indicated that reduced SLC22A7 (a gene-encoding organic anion transporter 2) expression in noncancerous liver tissue predicts hepatocellular …
Witryna30 paź 2024 · The transport of drugs across the placenta is a point of great importance in pharmacotherapy during pregnancy. However, the knowledge of drug transport in pregnancy is mostly based on experimental clinical data, and the underlying biological mechanisms are not fully understood. In this review, we summarize the current … f1 heute newsWitryna29 mar 2024 · Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. … does elden ring scale with levelWitryna9 paź 2012 · Finally, organic anion transport by OAT10 (SLC22A13) was reported to be driven by exchange with dicarboxylates or hydroxyl ions, similar to OAT4; however, ... Melnikov S, Dinour D. Urinary organic anion transporter protein profiles in AKI. Nephrol Dial Transplant. 2012; 27:1387–95. doi: 10.1093/ndt/gfr541. [Google Scholar] … f1hh-19e647-caWitrynaOrganic anion transporters (OATs) are the secondary/tertiary active transporter proteins that regulate anion balance in the body. They are primarily expressed in the kidney … f1hh-19805-abWitryna6 sie 2024 · Organic anion transporter (OAT) 2 and OAT7 were recently shown to be involved in the hepatic uptake of drugs; however, there is limited understanding of the … f1h falconWitrynaView/Edit Mouse. Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene. [5] OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the … does elden ring have cross progressionWitrynaAbstract. 1. Organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 are polyspecific transporters that mediate the transport of organic acids into … f1hh-6011-ba