Ctgf tumor

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August undefined, 2024

WebSep 1, 2024 · Connective tissue growth factor (CTGF) is a matricellular protein related to hepatic fibrosis. This study aims to clarify the roles of CTGF in hepatocellular carcinoma … WebJun 3, 2013 · Background The role of CTGF varies in different types of cancer. The purpose of this study is to investigate the involvement of CTGF in tumor progression and prognosis of human nasopharyngeal carcinoma (NPC). Experimental design CTGF expression levels were examined in NPC tissues and cells, nasopharynx (NP) tissues, and NP69 cells. The …

Efficiency of Promoters of Human Genes FAP and CTGF at …

WebJun 1, 2024 · Increasing evidence indicates that connective tissue growth factor (CTGF), a multifunctional signaling modulator, promotes cancer initiation, progression, and metastasis by regulating cell proliferation, migration, invasion, drug resistance, and epithelial–mesenchymal transition (EMT). CTGF is also involved in the tumor … WebCCN (for CYR61/ CTGF /NOV) proteins were identified originally from diverse cellular contexts and studied for their growth-promoting activities. It is now known that there are … gpwhealthcenter.org

Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor …

WebConnective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. ... CCN2 inhibits lung cancer … WebIn pancreatic cancer, CTGF is a critical regulator of tumor growth, and CTGF-specific antibody attenuates tumor growth and metastases in vivo [7, 8]. On the other hand, increased CTGF expression has been correlated with improved prognosis in chondrosarcoma patients and in patients with lung cancer [ 9 , 10 ]. gpw health center - manassas

The reactive tumor microenvironment: MUC1 signaling directly

CTGF antagonism with mAb FG-3019 enhances chemotherapy …

WebJul 18, 2024 · Dynamic interaction between prostate cancer and the bone microenvironment is a major contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co-culture model of PC3 prostate cancer cells and osteoblasts followed by microarray based gene expression profiling to identify previously unrecognized prostate … WebAug 8, 2024 · Lai, D., Ho, K. C., Hao, Y. & Yang, X. Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF. Cancer Res ... gpw health manassasWebAug 27, 2014 · (A) Fibroblasts were purified from Myc-CaP tumors 1 wk after sham operation or castration (C) (n = 10 per group), plated, and stimulated for 24 h with TGF-β1 (10 ng/mL), CTGF (50 ng/mL), or TGF-β1 plus CTGF. RNA was isolated, and expression of the indicated genes was analyzed as described earlier. gpw health center jobs

"WebMar 1, 2015 · Upon TGFβ1 stimulation, low-CTGF HCC cells formed tumors with a high stromal content and CTGF expression, which was inhibited by treatment with LY2109761. Blocking TGFβ signaling with LY2109761 or galunisertib inhibited CTGF synthesis and release by HCC cells and reduced tumor stromal content by inhibiting fibroblastic cell … " - Ctgf tumor

Ctgf tumor

Epithelial derived CTGF promotes breast tumor …

WebMar 21, 2024 · These eight phenotypes are “TNF- CTGF- GLUT4+”, “TNF- CTGF+ GLUT4-”, “TNF- CTGF+ GLUT4+”, “TNF+ CTGF- GLUT4-”, “TNF+ CTGF- GLUT4+”, “TNF+ CTGF+ GLUT4-”, ... M2 and tumor-associated macrophages (TAMs) type M1 (M1-TAM) and type M2 (M2-TAM) (Figure 1E). Using this computational approach, we found that insulin … WebJun 6, 2012 · Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis. Similar mechanisms are …

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WebAug 9, 2010 · MUC1 increases CTGF/CCN2 expression in pancreatic tumors cells. The MUC1.CT conducts signals from the cell surface by associating with and modifying the activity of transcriptional activators and ... WebOf late, there is accumulating evidence that CTGF expression is highly correlated with the development of cancers. 5 Elevated CTGF expression has been observed in mammary …

WebSep 4, 2024 · Connective tissue growth factor (CTGF) is a matricellular protein related to hepatic fibrosis. This study aims to clarify the roles of CTGF in hepatocellular carcinoma (HCC), which usually develops from fibrotic liver. CTGF was overexpressed in 93 human HCC compared with nontumorous tissues, primarily in tumor cells. WebWe examined in detail the molecular mechanisms of MUC1.CT signaling that induces the expression of connective tissue growth factor (CTGF/CCN2), a potent mediator of ECM remodeling and angiogenesis. We demonstrate a robust induction of CTGF synthesis and secretion in response to serum factors that is enabled only when MUC1 is highly expressed.

WebJun 16, 2024 · FibroGen's pamrevlumab is a first-in-class antibody that inhibits the activity of connective tissue growth factor (CTGF), which, in cancer, is characterized by promotion of tumor growth. WebConnective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis.

WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the …

WebSep 17, 2024 · Elevated expression of markers of gingival fibrosis (particularly CTGF), markers of epithelial–mesenchymal transition (EMT), periostin, and enzymes of the lysyl oxidase family have been documented in DIGO. ... phenotype and develop the mesenchymal phenotype during embryonic development, 12 fibrogenesis, 13 wound … gpw health center - woodbridgeWebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast … gpw health woodbridgeWebSep 9, 2015 · High expression of CTGF in breast tumor epithelial component correlates with poor clinical prognosis and outcomes. The interaction between tumor and stromal cells and their signaling output mould the microenvironment to support tumorigenesis and metastasis [].In this context, cytokines, chemokines, as well as growth, angiogenesis and … gp wheatfield in gypsumWebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... cancer, and infections. Glomerulonephritis is a common cause of end-stage renal failure. Severe and prolonged inflammation can … gp wheatfield inWebMar 3, 2004 · Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells, but few mechanistic details are known. We investigated the roles of CTGF and collapsin response mediator protein 1 (CRMP-1) in metastasis and invasion of human lung adenocarcinoma. gpwheroWebFeb 2, 2014 · Here, we define connective tissue growth factor (CTGF) as a therapeutic target for metastatic melanoma. Clinically, CTGF expression correlates with tumor progression and is strongly induced by hypoxia through HIF-1 and HIF-2-dependent mechanisms. Genetic inhibition of CTGF in human melanoma cells is sufficient to … gp wheatleyWebMar 10, 2024 · CTGF is overexpressed in triple-negative breast cancer. In a publicly available gene expression database, the Cancer Cell Line Encyclopedia portal, we … gp whetstone