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Cral-trio lipid binding domain

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebThe bipartite CRAL_TRIO motif is composed of a large lobe encoding a hydrophobic lipid-binding pocket (CRAL_TRIO_C) that is closed off by a smaller N-terminal lobe (CRAL_TRIO_N) . To analyze the lipid-binding activity of CPSFL1, we used recombinant affinity-purified Sec14 proteins and performed protein−lipid blot overlay assays (Fig. 5A, …

ZFIN Gene: triob - Zebrafish Information Network

WebJul 1, 2015 · The CRAL_TRIO domain is an N-terminal ligand binding region within a larger protein domain (SEC14) that takes its name from common sequence elements in cellular retinaldehyde binding protein (CRALBP) and the signaling domain of the TRIO guanine exchange factor (Panagabko et al., 2003). ... The SEC14 domain contains a … The Sec14 protein was the first CRAL-TRIO domain for which the structure was determined. The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and 5 form a parallel beta sheet with strands 1 and 6 being anti-parallel. The structure also identified a … See more CRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules. This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. See more C20orf121; MOSPD2; PTPN9; RLBP1; RLBP1L1; RLBP1L2; SEC14L1; SEC14L2; SEC14L3; SEC14L4; TTPA; See more • UMich Orientation of Proteins in Membranes families/superfamily-129 - Calculated spatial positions of CRAL-TRIO domains in membrane See more maria pure of heart https://hkinsam.com

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Webtriob. Predicted to have ATP binding activity; Rho guanyl-nucleotide exchange factor activity; and protein kinase activity. Predicted to be involved in axon guidance; central nervous system development; and protein phosphorylation. Human ortholog (s) of this gene implicated in autosomal dominant non-syndromic intellectual disability and ... WebFeb 15, 2024 · CRAL-TRIO lipid binding domain superfamily; KEGG Genes - Molecular building blocks of life in the genomic space. Dmel_CG30339; MARRVEL_MODEL - MARRVEL (model organism gene) 246549; modMine - A data warehouse for the modENCODE project. FBgn0050339; Linkouts. BioGRID ... WebThe Sec14 domain is depicted in yellow with N-terminal CRAL-TRIO domain as an oval structure. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] from ... natural grass killer for fence line

ZFIN Gene: nf1a - Zebrafish Information Network

Category:C34C12.6 CRAL-TRIO domain-containing protein …

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Cral-trio lipid binding domain

ZFIN Gene: bnipl - Zebrafish Information Network

WebApr 7, 2024 · The main feature of the CRAL-TRIO domain is that it possesses a cavity to specifically host a lipophilic molecule. CRAL-TRIO domain-containing proteins belong to the large category of lipid transfer proteins (Chiapparino et al., 2016). Sec14p can exchange glycerophospholipids (PI and PC) between membranes, whereas retinaldehyde-binding … WebAug 1, 2008 · • Proteins containing the lipid-binding Sec14 domain, also referred to as the CRAL-TRIO domain, ar e found throughout eukaryotic organisms ranging from yeast to humans.

Cral-trio lipid binding domain

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WebSep 1, 2009 · ProNGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786). By similarity. ... 3.40.525.10 CRAL-TRIO lipid binding domain 1 hit; 1.20.900.10 Dbl homology (DH) domain 2 hits; ... SSF52087 CRAL/TRIO domain 1 hit; SSF48065 DBL homology domain (DH-domain) 2 hits; WebSeveral CRAL-TRIO domain proteins have been shown to bind phospholipids in addition to their hydrophobic ligand (27,28), prompting us to test whether the CPSFL1 protein is capable of binding ...

WebCRAL-TRIO lipid binding domain superfamily PH-like domain superfamily Ras GTPase-activating domain Ras GTPase-activating protein Ras GTPase-activating protein, conserved site Rho GTPase activation protein; UniProtKB:E7FFY1. InterPro 2759: Transcripts Genome Browsers ... WebCRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules. This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. CRALB proptein carries 11-cis-retinol or 11-cis-retinaldehyde. It is a carrier that modulates interaction of retinoids with visual cycle enzymes.

WebThe CRAL-TRIO domain is a structurally conserved element of about 170 amino acids, which constitute a hydrophobic lipid binding pocket. The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and ... WebSuperfamily assignments for Oryza sativa ssp. Indica . Summary assignment statistics followed by sortable table of detailed assignments with number of domains, proteins and families assigned for each superfamily.

WebMay 10, 2016 · The deduced 354-amino acid protein contains a conserved CRAL-TRIO domain (residues 118-279) that is 45% identical to that in cellular retinaldehyde-binding protein (CRALBP, or RLBP1; 180090). The CRAL-TRIO domain is present in members of the lipid-binding SEC14-like proteins. RT-PCR analysis of 18 human tissues showed …

WebSpecific lipid-binding protein domains, such as PH, FYVE, PX, PHD, C2 and SEC14 homology domains, mediate interactions between proteins and specific phospholipids. Here we review the published literature, plus some of our most recent unpublished findings, regarding the biology of the SEC14 domain, also known as CRAL_TRIO domain. maria rasputin\\u0027s brother dmitri rasputinWebAug 23, 2024 · The N-terminal domain of yeast ECM25 protein has been identified as containing a lipid binding CRAL-TRIO domain. [3] Structure. The Sec14 protein was the first CRAL-TRIO domain for which the structure was determined. [4] The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and … natural grass near meWebSep 11, 2024 · While the SEC14 domain and its CRAL-TRIO-N-terminal extension serve general membrane attachment of the protein, the C-terminal GOLD domain directs it to the plasma membrane by recognizing specific phosphoinositides. ... Saito K, Tautz L, Mustelin T (2007a) The lipid-binding SEC14 domain. Biochim Biophys Acta 1771:719–726. CAS … maria rafaela haney braintreeWebCRAL-TRIO lipid binding domain CRAL-TRIO lipid binding domain superfamily; UniProtKB:F6NPA8. InterPro 334: UniProtKB:A5WV31. InterPro 367: Transcripts . Genome Browsers. UCSC NCBI Ensembl ZFIN. Type Name Length (nt) Analysis ; … maria rafols schoolWebAug 1, 2024 · CRALBP protein contains one CRAL-TRIO lipid-binding domain, of 162 aminoacids (136-297). As predicted by in-silico analysis, the c.398delC affects proline 133 and causes total disruption of CRAL-TRIO domain, resulting in a loss of ability to bind its ligands. CRAL-TRIO motifs usually bind small hydrophobic molecules. maria purkarthoferWebNov 1, 2024 · CRAL_TRIO family proteins are cytosolic and contain the SEC14 carboxy-terminal domain [7,9]. The CRAL_TRIO subgroup derives its name from the cellular retinaldehyde-binding protein (CRALBP) and the TRIO guanine exchange factor [11]. SEC14 was originally shown to be a cytosolic factor that promotes protein export from … maria ray fairfield ct obituaryWebCRAL-TRIO domain is a protein structural domain that binds small lipophilic molecules. This domain is named after cellular retinaldehyde-binding protein (CRALBP) and TRIO guanine exchange factor. ... The N-terminal domain of yeast ECM25 protein has been identified as containing a lipid binding CRAL-TRIO domain. maria ratm lyrics